WebJun 11, 2024 · Wild-type STAT3 plasmid, dominant-negative STAT3 plasmid (pGV492-Flag-STAT3-Y705F), FOXM1 shRNA (shFOXM1) and scrambled shRNA (shNC) lentivirus were purchased from Hanheng Biotechnology (Hanheng Biotechnology Co., Ltd., Shanghai, China). Cells were plated into six-well plates and infected with plasmids and shRNA … WebThe FOXM1 shRNA (TRCN0000273984) sequence was retrieved from the Broad Genetic Perturbation Platform Web Portal. Oligos corresponding to the shRNA were annealed and ligated into Tet-pLKO-puro. These plasmids were created by your colleagues. Please acknowledge the Principal Investigator, cite the article in which the plasmids were …
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WebOct 7, 2015 · ShRNA-mediated FoxM1 inhibition significantly impeded clonogenic growth and survival of patient-derived primary GBM cells with marked downregulation of Sox2, a master regulator of stem cell … WebFOXM1 has been shown to exert its oncogenic effects via several mechanisms, including its promotion of cell cycle progression, tissue invasion, angiogenesis, metastasis, withdrawal from cellular senescence, resistance to DNA damaging agents, … chiropodist lymm
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WebJun 11, 2024 · FOXM1 is a transcription factor for DKK1 DKK1 expression was reduced at the protein and mRNA levels by two different shRNAs against FOXM1 in S2-CP8, HPAF-II, TE-1, TE-5, and TE-8 cells (Fig. 4A, B ). WebOct 18, 2011 · Therefore, FoxM1 perturbed the balance between progenitor cell renewal and the commitment to differentiation. Moreover, these effects of sh-FoxM1 were rescued by shRNA-resistant R286A/H287A or β … WebHMGA2 is essential for sustaining cell proliferation in mt-Low HCC cells. Interestingly, HMGA2 levels precisely mirrored those of FOXM1/BMYB in the HCC cell lines. 6 Moreover, the levels tended to inversely correlate with those of the p27 protein, but not mRNA, levels (Figure 1B,C; P27KIP1).These observations raised the possibility that HMGA2 has a role … chiropodist mablethorpe