Graph pangenome captures missing heritability
WebGraph pangenome captures missing heritability and empowers tomato breeding. Y Zhou, Z Zhang, Z Bao, H Li, Y Lyu, Y Zan, Y Wu, L Cheng, Y Fang, K Wu, ... Nature 606 (7914), 527-534, 2024. 41: 2024: Genome‐wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep. WebGraph pangenome captures missing heritability and empowers tomato breeding. Yao Zhou; Zhiyang Zhang; Zhigui Bao; Hongbo Li; Yaqing Lyu; Y. Zan; Yaoyao Wu; Lin Cheng; Yuhan Fang; Kun Wu; Jinzhe Zhang; Hongjun Lyu; Tao Lin; Qiang Gao; 7 more; Sanwen Huang; Nature. Published on 08 Jun 2024. 0 views
Graph pangenome captures missing heritability
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WebJun 16, 2024 · PDF Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits1,2. The solution... Find, … WebThis graph pangenome was used for genome-wide association study analyses and heritability estimation of 20,323 gene-expression and metabolite traits. The average estimated trait heritability is 0.41 compared with 0.33 when using the single linear reference genome. This 24% increase in estimated heritability is largely due to resolving ...
WebZhou et al. (2024) demonstrated the importance of such a graph-based pangenome by comparing the heritability of more than 20,000 molecular traits when variants were inferred using the linear ... Web(93.9%)genes,somewithlargecis-heritability,withoutanysignificant cis- eQTLs(ExtendedDataFig.7a).Ourstudyclearlysuggeststhatallelic …
WebJun 8, 2024 · These data indicate that the capture of missing heritability through the graph pangenome is largely due to the inclusion of more identified SVs. Incomplete LD … WebIn the SLU Publication database search interface you can search for and find information on research publications from the Swedish University of Agricultural Sciences (SLU), as well as access to full text when available. In addition to searching for publications, you can also find publications by searching for an author, or by faculty or department.
WebI originally designed LDAK to enable more precise estimation of "SNP heritability," the total proportion of phenotypic variation explained by all SNPs. Accurate estimates of SNP heritability are important for knowing the potential of GWAS and of SNPbased prediction models, and resolving the missing heritability debate. ... Graph pangenome ...
WebCapturing missing heritability To test the power of the graph pangenome in capturing missing heritability, we used LDAK 34 to estimate the variant heritability of 20,323 … sims 4 ghostfaceWebTea plant (Camellia sinensis) is a widely cultivated cash crop and tea is a favorite functional food in the world. Fresh tea leaves (FTLs) play a critical role in bridging the two fields closely related to tea cultivation and tea processing, those are, tea plant biology and tea biochemistry. To provide a comprehensive overview of the development stages, … sims 4 ghost eyesWebGraph pangenome captures missing heritability and empowers tomato breeding. Nature. 2024; 606: 527-534. Crossref; PubMed; Scopus (29) Google Scholar). Indeed, the average estimated trait heritability could be increased by 24% through a graph pan-genome compared with that using a single linear reference genome rb thcgjhnWebPanKmer is a toolkit designed for reference-free analysis of pangenome datasets consisting of dozens to thousands of individual genomes, and provides researchers with a valuable and convenient means to explore the full scope of genetic variation in a population, without reference bias. Summary Pangenomes are replacing single reference genomes as the … rb that\\u0027sWebGuillenea, A. (2024). Genomic prediction and QTL mapping in multi-breed and crossbred cattle populations considering breed origin of the alleles.Aarhus Universitet. rb-thannhausenWebZhou et al. (2024) demonstrated the importance of such a graph-based pangenome by comparing the heritability of more than 20,000 molecular traits when variants were inferred using the linear ... rbth croatiaWebGraph pangenome captures missing heritability and empowers tomato breeding. Nature 2024-06-16 Journal article DOI: 10.1038/s41586-022-04808-9 Contributors: Yao Zhou; Zhiyang Zhang; Zhigui Bao; Hongbo Li; Yaqing Lyu; Yanjun Zan; Yaoyao Wu; Lin Cheng; Yuhan Fang; Kun Wu et al. Show more detail. Source: ... rb that\u0027ll