Phospholipase a2 receptor antibody pla2r

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August undefined, 2024

WebSep 18, 2024 · Serum anti-phospholipase A2 receptor (PLA2R) antibody detected at diagnosis as a predictor for clinical remission in patients with primary membranous nephropathy: a meta-analysis Yufeng Liang, Jianxin Wan, Yongping Chen & Yangbin Pan BMC Nephrology 20, Article number: 360 ( 2024 ) Cite this article 7470 Accesses 11 … WebFeb 20, 2024 · M-type phospholipase A2 receptor 1 (PLA2R) has been described as a major antigen in iMN, with anti-PLA2R antibodies (Abs) present in ∼70% of incident patients [ 2, 3 ]. The specificity of anti-PLA2R Abs for the diagnosis of iMN, albeit not absolute, is now well established [ 3–5 ].

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WebMay 29, 2024 · The aims of this study were to detect the expression of M phospholipase A2 receptor (PLA2R) in the kidney tissue of patients with idiopathic membranous nephropathy (IMN), secondary membranous nephropathy (SMN), and the nonmembranous nephropathy (non-MN), to evaluate the value of PLA2R in the kidney tissue and serum anti-PLA2R … WebAnti-phospholipase A2 receptor antibody (anti-PLA2R) has emerged as a reliable biomarker for diagnosis, monitoring of disease activity and response to therapy in primary MN. … sideways pumpkin carving ideas

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WebAnti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. If a patient is already known to have anti … WebBackground: The presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of spontaneous remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this problem. Here, we conducted a comprehensive meta-analysis to … WebJan 3, 2024 · Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported. the poems of john byrom

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WebJul 15, 2024 · (a) PM2.5 induces extrarenal anti-PLA2R antibody production. Inhalation of PM2.5 results in the accumulation and activation of alveoli macrophages and neutrophils. PLA2R that is presented on these cells can be discharged into the inflammatory space, when neutrophil extracellular traps (NETs) and macrophage extracellular traps (METs) are … WebNational Center for Biotechnology Information the poem she walks in beautyWebMar 5, 2015 · Hoxha, E. et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int. 82, 797–804 (2012). the poems of ernest dowson

"WebMar 11, 2024 · Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) with circulating serum autoantibodies to PLA2R (SAb+) but no deposits of PLA2R antigen in glomerular tissue by immunofluorescence (GAg−) has been reported. However, little is known about the clinicopathological characteristics or prognosis of this subtype of … " - Phospholipase a2 receptor antibody pla2r

Phospholipase a2 receptor antibody pla2r

WebRecent studies have shown that in approximately 70% of patients with primary MN (pMN), the immune complexes consist of autoantibodies against the podocyte protein M-type phospholipase A2 receptor (PLA2R).(1) There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression.(2) The presence of ... WebThe Phosphlipase A2 receptor (PLA2R) was recently discovered as a target autoantigen in patients with idiopathic membranous nephropathy (IMN). Autoantibodies directed to …

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WebThe discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary target in membranous nephropathy (MN) greatly advanced basic and clinical research. … Web因此有学者提出，磷脂酶A2可评估IMN的临床疗效与预后。本文拟对此研究状况做以综述。一、PLA2R的结构. PLA2R属于甘露糖受体（Mannose Receptor，MR）家族，1989年由Stanescu等[5]首次对其做了报道。迄今为止，共发现了两个亚型的PLA2R——M型和N型[6]。

WebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay … WebDec 15, 2024 · The discovery of the phospholipase A2 receptor (PLA2R) antibody in 2009 has induced a paradigm shift in both the diagnosis and monitoring of patients. Two serological tests are routinely used: the enzyme-linked immunosorbent assay (ELISA), which is quantitative, and the immunofluorescence assay (IFA), which is more sensitive.

WebPhospholipase A2 Receptor (PLA2R) Antibody, ELISA - Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing … WebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy …

WebJun 15, 2024 · Materials and methods: An open-label prospective comparative study included 56 PMN patients (pts) with nephrotic syndrome (NS) and high serum level of antibodies to the phospholipase A2 receptor anti-PLA2R (mean age 5112 years, men 70%). We recorded demographic and clinical parameters at the time of kidney biopsy, data from … the poems of mark akenside m dWebSep 18, 2024 · Currently, serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) is emerging as a predictive biomarker for early prognosis of PMN. In 2009, Beck et al. [ 2 ] … the poems of henry wadsworth longfellowWebAnti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R. This test can be used to identify … the poems of john godfrey saxeWebMar 10, 2024 · The M-type phospholipase A2 receptor (PLA2R) has been identified as the main target antigen in the pathogenesis of iMN . Some evidence suggests that IgG4 anti-PLA2R antibodies can bind MBL to activate the lectin complement pathway . Based on this evidence, we hypothesized that MBL-initiated complement activation is involved in the … the poems of laurence minot 1333 1352WebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay systems for anti-PLA2R antibody (Ab) have been developed. sideways pushed knitted replacementWebApr 15, 2024 · Both blood phospholipase A2 receptor -Ab and kidney tissue phospholipase A2 receptor were negative. Thirty-six patients received glucocorticosteroids and/or immunosuppressants. ... (ANA), ds-DNA, complement C3 and C4, and antiphospholipase A2 receptor (PLA2R) antibodies. Pathological data. All patients underwent a renal biopsy. … sideways punk baseball capWebApr 11, 2024 · Approximately 80% of PMN cases arise due to autoantibodies that recognize the phospholipase A2 receptor (PLA2R) antigen expressed on podocytes. Anti-PLA2R is both a diagnostic and prognostic biomarker, and total aPLA2R antibody level has been shown to be a biomarker for prognosis of outcome in patients with PMN. sideways queen bed frame